Department

Department may refer to:

Government and military

DEPT

DEPT may refer to:

DEPT (medicine)

Directed Enzyme Prodrug Therapy (DEPT) uses enzymes artificially introduced into the body to convert Prodrugs, which have no or poor biological activity, to the active form in the desired location within the body. Many chemotherapy drugs for cancer lack tumour specificity and the doses required to reach therapeutic levels in the tumour are often toxic to other tissues. DEPT strategies are an experimental method of reducing the systemic toxicity of a drug, by achieving high levels of the active drug only at the desired site. This article describes the variations of DEPT technology.

Antibody-directed enzyme prodrug therapy (ADEPT)

ADEPT is a strategy to overcome the problems of lack of tumor selectivity. An antibody designed/developed against a tumor antigen is linked to an enzyme and injected to the blood, resulting in selective binding of the enzyme in the tumor. When the discrimination between tumor and normal tissue enzyme levels is sufficient, a prodrug is administrated into the blood circulation, which is converted to an active cytotoxic drug by the enzyme, only within the tumor. Selectivity is achieved by the tumor specificity of the antibody and by delaying prodrug administration until there is a large differential between tumor and normal tissue enzyme levels.

.travel

The domain name .travel is a top-level domain in the Domain Name System of the Internet. Its name suggests the intended and restricted use by travel agents, airlines, bed and breakfast operators, tourism bureaus, and others in the travel industry.

It is sponsored by Tralliance Registry Management Company (TRMC). Registrations are processed via accredited registrars.

History

The domain was approved by ICANN on April 8, 2005 as a sponsored TLD in the second group of new TLD applications evaluated in 2004. TheGlobe.com acquired Tralliance Corporation, the operator of .travel, on May 9, 2005.

The official launch began in October 2005, with a screening process to determine eligibility to register domains in each of three monthly groups for October, November and December. Open registrations began in January 2006. Governments were given priority registration for geographic place names from July 2005 to December 21, 2007.

A 2006 proposal that a wildcard DNS record point all unused *.travel domains to Tralliance's search.travel site was rejected by ICANN due to technical considerations.

Travel

Travel is the movement of people between relatively distant geographical locations, and can involve travel by foot, bicycle, automobile, train, boat, airplane, or other means, with or without luggage, and can be one way or round trip. Travel can also include relatively short stays between successive movements.

Etymology

The origin of the word "travel" is most likely lost to history. The term "travel" may originate from the Old French word travail. According to the Merriam Webster dictionary, the first known use of the word travel was in the 14th century. It also states that the word comes from Middle English travailen, travelen (which means to torment, labor, strive, journey) and earlier from Old French travailler (which means to work strenuously, toil). In English we still occasionally use the words travail and travails, which mean struggle. According to Simon Winchester in his book The Best Travelers' Tales (2004), the words travel and travail both share an even more ancient root: a Roman instrument of torture called the tripalium (in Latin it means "three stakes", as in to impale). This link reflects the extreme difficulty of travel in ancient times. Also note the torturous connotation of the word "travailler." Today, travel may or may not be much easier depending upon the destination you choose (i.e., Mt. Everest, the Amazon rainforest), how you plan to get there (tour bus, cruise ship, or oxcart), and whether or not you decide to "rough it (see extreme tourism and adventure travel). "There's a big difference between simply being a tourist and being a true world traveler," notes travel writer Michael Kasum. This is, however, a contested distinction as academic work on the cultures and sociology of travel has noted.

List of Rob & Big episodes

The following is an episode list for the MTV television series Rob & Big. The show follows the lives of professional skateboarder Rob Dyrdek and his best friend and bodyguard Christopher "Big Black" Boykin. The series premiered on November 2, 2006 and featured eight episodes in each of its first and second seasons and sixteen episodes in the concluding third season. Along with the regular episodes, the series feature three recap specials.

Overview

Episodes

Season 1 (2006)

Season 2 (2007)

Season 3 (2008)

Specials

References